Backdrop Health enables pharmaceutical companies to bring new therapies to market more quickly and economically, healthcare providers to preemptively identify health issues and improve patient outcomes, and insurers to optimize patient health at lower cost. The company leverages a novel machine learning approach to analyze electronic medical records (EMRs) and other patient data, creating an explainable probabilistic knowledge graph and a binomial-based comorbidity discovery technique. Its platform amplifies effective dataset size without stratification, enhancing the value of both licensed and in-house patient data. This innovation accelerates clinical trials by improving inclusion/exclusion criteria precision and enabling synthetic control arms for real-world evidence studies.