The Human Phenotype Project is a landmark effort to empower researchers to make the next breakthroughs in human health. By profiling a diverse participant base of individuals beyond the genome, and incorporating a wealth of now-measurable data layers and environmental influences, ‘deep phenotyping’ gathers the details of human health and disease. This novel approach brings together many pieces of the puzzle and builds a high-resolution view of the key drivers behind health and disease. Following in the wake of the Human Genome Project, The Human Phenotype Project will impact the way we approach and treat a wide range of diseases that plague human health.